1,4-Diazepanes derived from ( S)-serine – Homopiperazines with improved σ 1 (sigma) receptor affinity and selectivity

Starting from the proteinogenic amino acid ( S)-serine chiral non-racemic 1,4-diazepanes 4 with a hydroxymethyl residue in position 2 are synthesized and pharmacologically evaluated. The key step in the synthesis is the formation of the bicyclic system 8 by consecutive nucleophilic substitution of t...

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Bibliographic details
Volume: 44
Main Author: Bedürftig, Stephan
Wünsch, Bernhard
Format: Journal Article
Language: English
Place of publication: Elsevier Masson SAS 2009
published in: European journal of medicinal chemistry Vol. 44; no. 2; pp. 519 - 525
Data of publication: 2009
ISSN: 0223-5234
1768-3254
EISSN: 1768-3254
Discipline: Chemistry
Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: available in Bonn?
Database: Database information not found
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