Synthesis of bridged piperazines with If receptor affinity

Bridged piperazines 4 were designed as conformationally restricted piperazine I receptor ligands. The chiral pool synthesis started from (S)-glutamate, which was transformed in five reaction steps into the piperazinediones 5 bearing a propionic acid ester side chain. A two-step Dieckmann analogous c...

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Bibliographic details
Volume: 42
Main Author: Weigl, Manuela
Wunsch, Bernhard
Format: Journal Article
Language: English
Zielgruppe: Academic
Place of publication: Elsevier B.V 01.10.2007
published in: European journal of medicinal chemistry Vol. 42; no. 10; p. 1247
Data of publication: 20071001
ISSN: 0223-5234
1768-3254
EISSN: 1768-3254
Discipline: Chemistry
Pharmacy, Therapeutics, & Pharmacology
Subjects:
Online Access: available in Bonn?
Database: Academic OneFile (A&I only)
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